Team 4 – Membrane dynamics
We wish to understand how membrane trafficking and membrane transport processes shape the maintenance and adaptive homeostasis of mammalian cells, with a strong but not exclusive interest in neurons and synapses. We are particularly interested in two cell compartments, the lysosome and the dendritic spine.
Team leaders
Christine Anne-Longin, Research Scientist, PI, INSERM, Team 4 - Membrane dynamicschristine.anne-longin@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 27, room 616
Bruno Gasnier, Senior Research Scientist, PI, CNRS, Team 4 - Membrane dynamicsbruno.gasnier@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 15, room 626
Members
Francine Acher, Senior Research Scientist Emeritus, CNRS, Team 4 - Membrane dynamicsfrancine.acher@-Code to remove to avoid SPAM-parisdescartes.fr, +33 1 70 64 99 19, room 626
Damien Carrel, Assistant Professor, Université Paris Cité, Team 4 - Membrane dynamicsdamien.carrel@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 12, room 630
Cécile Jouffret, Engineer, Core unit, Team 4 - Membrane dynamicscecile.jouffret@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 30, room 616
Jade Mailliart, Master Student, Team 4 - Membrane dynamicsjade.mailliart@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 27, room 616- Christos Matsingos, Postdoctoral Researcher, Team 4 - Membrane dynamicschristos.matsingos@-Code to remove to avoid SPAM-u-paris.fr, room 626
- Alexandra Matta, Postdoctoral Researcher, Team 4 - Membrane dynamicsalexandra.matta@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 29, room 626
Hynda Mimouni, Technician, Université Paris Cité, Team 4 - Membrane dynamicshynda.mimouni@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 30, room 616- Elodie Phommabouth, Technician, Université Paris Cité, Team 4 - Membrane dynamicselodie.phommabouth@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 30, room 616
- Andrea Richerolle, Engineer, Team 4 - Membrane dynamicsandrea.richerolle@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 23, room 626
Corinne Sagné, Research Scientist, INSERM, Team 4 - Membrane dynamicscorinne.sagne@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 16, room 616- Chang Zheng, Doctoral Student, Team 4 - Membrane dynamicschang.zheng@-Code to remove to avoid SPAM-etu.u-paris.fr, +33 1 70 64 99 29, room 626
Former members
Claire Desnos, Research Scientist, CNRS until 2022, Team 4 - Membrane dynamicsclaire.desnos@-Code to remove to avoid SPAM-u-paris.fr
Floriane Eshak, Postdoctoral Researcher until 2024, Team 4 - Membrane dynamicsfloriane.eshak@-Code to remove to avoid SPAM-parisdescartes.fr
Isabelle Fanget, Engineer, CNRS until 2021, Team 4 - Membrane dynamicsisabelle.fanget@-Code to remove to avoid SPAM-u-paris.fr
Margaux Gleizes, PhD Student until 2023, Team 4 - Membrane dynamicsmargaux.gleizes@-Code to remove to avoid SPAM-u-paris.fr- Océane Guelle, Postdoctoral Researcher until 2024, Team 4 - Membrane dynamicsoceane.guelle@-Code to remove to avoid SPAM-u-paris.fr
Erdem Karatekin, Visitor - Yale University until 2022, Team 4 - Membrane dynamicserdem.karatekin@-Code to remove to avoid SPAM-yale.edu
Solène Lebrun, Assistant engineer, CNRS until 2022, Team 4 - Membrane dynamicssolene.lebrun@-Code to remove to avoid SPAM-u-paris.fr- Isaure Lot, Postdoctoral Researcher until 2023, Team 4 - Membrane dynamicsisaure.lot@-Code to remove to avoid SPAM-u-paris.fr, +33 1 70 64 99 27
Pauline Moracchini, Master Student until 2023, Team 4 - Membrane dynamicspauline.moracchini@-Code to remove to avoid SPAM-etu.utc.fr, +33 1 70 64 99 23
Anne Marie Mukundwa, Master Student until 2023, Team 4 - Membrane dynamicsanne-marie.mukundwa@-Code to remove to avoid SPAM-etu.utc.fr, +33 1 70 64 99 27
Recent Publications
Articles
- Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome.
Takyi RB, Plantin J, Charron S, Maier MA, Baron JC, Turc G, Rosso C, Debacker C, Lindberg PG : Brain Commun, 2025 - Roles of lysosomal small-molecule transporters in metabolism and signaling.
Damme M, Guelle O, Löw C, Gasnier B : Trends Cell Biol, 2025 - Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor.
Matsingos C, Howell LA, McCormick PJ, Fornili A : J Mol Biol, 2024 - MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
Katharina Esther Julia Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov, Florian Gabriel, Cécile Debacker, Julien Dairou, Isabelle McCort-Tranchepain, Nouf N Laqtom, Sze Ham Chan, Akika Ejima, Kenji Sato, David Massa López, Paul Saftig, Ahmad Reza Mehdipour, Monther Abu-Remaileh, Bruno Gasnier, Christian Löw, Markus Damm : Nature Cell Biology, 2024 - Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain.
Cristiano N, Cabayé A, Brabet I, Glatthar R, Tora A, Goudet C, Bertrand HO, Goupil-Lamy A, Flor PJ, Pin JP, McCort-Tranchepain I, Acher FC : J Med Chem, 2024 - Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques.
Eshak F, Pion L, Scholler P, Nevoltris D, Chames P, Rondard P, Pin JP, Acher FC, Goupil-Lamy A : J Chem Inf Model, 2024 - Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu(2) Receptor Agonist.
Liu N, Eshak F, Malhaire F, Brabet I, Prézeau L, Renard E, Pin JP, Acher FC, Staudt M, Bunch L : J Med Chem, 2024 - Journaling as an effective tool to promote metacognition and enhance study methods in a pharmacology course, during and after the pandemic
Pena-Silva R A, Velasco-Castro J M, Matsingos C, Jaramillo-Rincon S X : The FASEB Journal, 2022 - hTERT DNA Methylation Analysis Identifies a Biomarker for Retinoic Acid-Induced hTERT Repression in Breast Cancer Cell Lines.
Nguyen E, Richerolle A, Sánchez-Bellver J, Varennes J, Ségal-Bendirdjian E : Biomedicines, 2022 - Enzyme replacement therapy: current challenges and drug delivery prospects via extracellular vesicles
Silva A K, Sagné C, Gazeau F, Abasolo I : Rare Disease and Orphan Drugs Journal, 2022 - Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping.
Felder S, Sagné C, Benedetti E, Micouin L : ACS Chem Biol, 2022 - Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration.
Liang C, Carrel D, Singh NK, Hiester LL, Fanget I, Kim H, Firestein BL : ASN Neuro, 2022 - Metabotropic glutamate receptor orthosteric ligands and their binding sites.
Acher FC, Cabayé A, Eshak F, Goupil-Lamy A, Pin JP : Neuropharmacology, 2022 - Aplicaciones de la inteligencia artificial en la farmacolog{\’\i}a b{\’a}sica y cl{\’\i}nica
Matsingos C, Urdaneta A M, Hern{\’a}ndez J C, Silva R A P : Medicina, 2021 - Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents
Christos Matsingos, Taha Al-Adhami, Shirin Jamshidi, Charlotte Hind, Melanie Clifford, J Mark Sutton, Khondaker Miraz Rahman : Bioorganic & medicinal chemistry, 2021 - Optoproteomics elucidates the interactome of L-type amino acid transporter 3 (LAT3).
Wang L, Sun X, Lu L, Marie A, Carrel D, Zhao S, Mille C, Song Q, Zhang Y, Ye S : Chem Commun (Camb), 2021 - Optoproteomics elucidates the interactome of L-type amino acid transporter 3 (LAT3).
Wang L, Sun X, Lu L, Marie A, Carrel D, Zhao S, Mille C, Song Q, Zhang Y, Ye S : Chem Commun (Camb), 2021 - A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers.
Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, Pin JP : Proc Natl Acad Sci U S A, 2021 - LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats.
De Sa Nogueira D, Bourdy R, Filliol D, Quessada C, McCort-Tranchepain I, Acher F, Zwiller J, Romieu P, Befort K : Neurosci Lett, 2021 - Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.
Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, Zdebik AA, Pusch M, Gasnier B : Proc Natl Acad Sci U S A, 2021 - A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity.
Khamsing D, Lebrun S, Fanget I, Larochette N, Tourain C, de Sars V, Brunstein M, Oheim M, Carrel D, Darchen F, Desnos C : Mol Brain, 2021 - Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters.
Gasnier B : Proc Natl Acad Sci U S A, 2021 - Free sialic acid storage disorder: Progress and promise.
Huizing M, Hackbarth ME, Adams DR, Wasserstein M, Patterson MC, Walkley SU, Gahl WA, FSASD Consortium : Neurosci Lett, 2021
Chapter
- Functional Study of Lysosomal Nutrient Transporters
Leray X, Sagné C, Gasnier B : extracted from Ion and Molecule Transport in Lysosomes Bruno Gasnier, Michael X Zhu - CRC Press, Taylor & Francis Group, ISBN:9781138560390, 2021