Team 4 – Membrane dynamics
We wish to understand how membrane trafficking and membrane transport processes shape the maintenance and adaptive homeostasis of mammalian cells, with a strong but not exclusive interest in neurons and synapses. We are particularly interested in two cell compartments, the lysosome and the dendritic spine.
Team leader
Bruno Gasnier, Senior Research Scientist, PI, CNRS, Team 4 - Membrane dynamics, +33 1 70 64 99 15, room 626
Members
Francine Acher, Senior Research Scientist Emeritus, CNRS, Team 4 - Membrane dynamics, +33 1 70 64 99 19, room 626
Christine Anne-Longin, Research Scientist, INSERM, Team 4 - Membrane dynamics, +33 1 70 64 99 27, room 616
Damien Carrel, Assistant Professor, Université Paris Cité, Team 4 - Membrane dynamics, +33 1 70 64 99 12, room 626
Hynda Mimouni, Technician, Université Paris Cité, Team 4 - Membrane dynamics, +33 1 70 64 99 30, room 616
- Elodie Phommabouth, Technician, Université Paris Cité, Team 4 - Membrane dynamics, +33 1 70 64 99 30, room 616
Former members
Recent Publications
Articles
- Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor.
Matsingos C, Howell LA, McCormick PJ, Fornili A : J Mol Biol, 2024 - MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
Katharina Esther Julia Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov, Florian Gabriel, Cécile Debacker, Julien Dairou, Isabelle McCort-Tranchepain, Nouf N Laqtom, Sze Ham Chan, Akika Ejima, Kenji Sato, David Massa López, Paul Saftig, Ahmad Reza Mehdipour, Monther Abu-Remaileh, Bruno Gasnier, Christian Löw, Markus Damm : Nature Cell Biology, 2024 - Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain.
Cristiano N, Cabayé A, Brabet I, Glatthar R, Tora A, Goudet C, Bertrand HO, Goupil-Lamy A, Flor PJ, Pin JP, McCort-Tranchepain I, Acher FC : J Med Chem, 2024 - Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques.
Eshak F, Pion L, Scholler P, Nevoltris D, Chames P, Rondard P, Pin JP, Acher FC, Goupil-Lamy A : J Chem Inf Model, 2024 - Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu(2) Receptor Agonist.
Liu N, Eshak F, Malhaire F, Brabet I, Prézeau L, Renard E, Pin JP, Acher FC, Staudt M, Bunch L : J Med Chem, 2024 - Journaling as an effective tool to promote metacognition and enhance study methods in a pharmacology course, during and after the pandemic
Pena-Silva R A, Velasco-Castro J M, Matsingos C, Jaramillo-Rincon S X : The FASEB Journal, 2022 - hTERT DNA Methylation Analysis Identifies a Biomarker for Retinoic Acid-Induced hTERT Repression in Breast Cancer Cell Lines.
Nguyen E, Richerolle A, Sánchez-Bellver J, Varennes J, Ségal-Bendirdjian E : Biomedicines, 2022 - Enzyme replacement therapy: current challenges and drug delivery prospects via extracellular vesicles
Silva A K, Sagné C, Gazeau F, Abasolo I : Rare Disease and Orphan Drugs Journal, 2022 - Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping.
Felder S, Sagné C, Benedetti E, Micouin L : ACS Chem Biol, 2022 - Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration.
Liang C, Carrel D, Singh NK, Hiester LL, Fanget I, Kim H, Firestein BL : ASN Neuro, 2022 - Metabotropic glutamate receptor orthosteric ligands and their binding sites.
Acher FC, Cabayé A, Eshak F, Goupil-Lamy A, Pin JP : Neuropharmacology, 2022 - Aplicaciones de la inteligencia artificial en la farmacolog{\’\i}a b{\’a}sica y cl{\’\i}nica
Matsingos C, Urdaneta A M, Hern{\’a}ndez J C, Silva R A P : Medicina, 2021 - Synthesis, microbiological evaluation and structure activity relationship analysis of linezolid analogues with different C5-acylamino substituents
Christos Matsingos, Taha Al-Adhami, Shirin Jamshidi, Charlotte Hind, Melanie Clifford, J Mark Sutton, Khondaker Miraz Rahman : Bioorganic & medicinal chemistry, 2021 - Optoproteomics elucidates the interactome of L-type amino acid transporter 3 (LAT3).
Wang L, Sun X, Lu L, Marie A, Carrel D, Zhao S, Mille C, Song Q, Zhang Y, Ye S : Chem Commun (Camb), 2021 - Optoproteomics elucidates the interactome of L-type amino acid transporter 3 (LAT3).
Wang L, Sun X, Lu L, Marie A, Carrel D, Zhao S, Mille C, Song Q, Zhang Y, Ye S : Chem Commun (Camb), 2021 - A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers.
Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, Pin JP : Proc Natl Acad Sci U S A, 2021 - LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats.
De Sa Nogueira D, Bourdy R, Filliol D, Quessada C, McCort-Tranchepain I, Acher F, Zwiller J, Romieu P, Befort K : Neurosci Lett, 2021 - Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.
Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, Zdebik AA, Pusch M, Gasnier B : Proc Natl Acad Sci U S A, 2021 - A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity.
Khamsing D, Lebrun S, Fanget I, Larochette N, Tourain C, de Sars V, Brunstein M, Oheim M, Carrel D, Darchen F, Desnos C : Mol Brain, 2021 - Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters.
Gasnier B : Proc Natl Acad Sci U S A, 2021 - Free sialic acid storage disorder: Progress and promise.
Huizing M, Hackbarth ME, Adams DR, Wasserstein M, Patterson MC, Walkley SU, Gahl WA, FSASD Consortium : Neurosci Lett, 2021 - Beta-arrestins operate an on/off control switch for focal adhesion kinase activity.
Alexander RA, Lot I, Saha K, Abadie G, Lambert M, Decosta E, Kobayashi H, Beautrait A, Borrull A, Asnacios A, Bouvier M, Scott MGH, Marullo S, Enslen H : Cell Mol Life Sci, 2020 - Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression.
Orrico-Sanchez A, Chausset-Boissarie L, Alves de Sousa R, Coutens B, Rezai Amin S, Vialou V, Louis F, Hessani A, Dansette PM, Zornoza T, Gruszczynski C, Giros B, Guiard BP, Acher F, Pietrancosta N, Gautron S : Mol Psychiatry, 2020 - Illuminating the allosteric modulation of the calcium-sensing receptor.
Liu H, Yi P, Zhao W, Wu Y, Acher F, Pin JP, Liu J, Rondard P : Proc Natl Acad Sci U S A, 2020 - LSP5-2157 a new inhibitor of vesicular glutamate transporters.
Poirel O, Mamer LE, Herman MA, Arnulf-Kempcke M, Kervern M, Potier B, Miot S, Wang J, Favre-Besse FC, Brabet I, Laras Y, Bertrand HO, Acher F, Pin JP, Puel JL, Giros B, Epelbaum J, Rosenmund C, Dutar P, Daumas S, El Mestikawy S, Pietrancosta N : Neuropharmacology, 2020 - Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism.
Mikou A, Cabayé A, Goupil A, Bertrand HO, Mothet JP, Acher FC : Sci Rep, 2020 - Transporters in acidic organelles.
Moriyama Y, Gasnier B : Biochim Biophys Acta Biomembr, 2020 - Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C : J Med Chem, 2020
Book
- Ion and Molecule Transport in Lysosomes
Bruno Gasnier, Michael X Zhu : CRC Press, Taylor & Francis Group, ISBN:9781138560390, (239 pages), 2020
Chapter
- Functional Study of Lysosomal Nutrient Transporters
Leray X, Sagné C, Gasnier B : extracted from Ion and Molecule Transport in Lysosomes Bruno Gasnier, Michael X Zhu - CRC Press, Taylor & Francis Group, ISBN:9781138560390, 2021