Recent Publications

Articles

• Enzyme replacement therapy: current challenges and drug delivery prospects via extracellular vesicles
  Silva A K, Sagné C, Gazeau F, Abasolo I : Rare Disease and Orphan Drugs Journal, 2022
• Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping.
  Felder S, Sagné C, Benedetti E, Micouin L : ACS Chem Biol, 2022
• Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B-trafficking proteins ABCD4 and LMBD1.
  Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR : J Biol Chem, 2017
• SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
  Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C : Proc Natl Acad Sci U S A, 2017
• An extended proteome map of the lysosomal membrane reveals novel potential transporters. (PDF)
  Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A : Mol Cell Proteomics, 2013
• Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. (PDF)
  Jézégou A, Llinares E, Anne C, Kieffer-Jaquinod S, O\\’Regan S, Aupetit J, Chabli A, Sagné C, Debacker C, Chadefaux-Vekemans B, Journet A, André B, Gasnier B : Proc Natl Acad Sci U S A, 2012
• Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin.
  Ruivo R, Bellenchi GC, Chen X, Zifarelli G, Sagné C, Debacker C, Pusch M, Supplisson S, Gasnier B : Proc Natl Acad Sci U S A, 2012
• Successful prediction of substrate-binding pocket in SLC17 transporter sialin. (PDF)
  Pietrancosta N, Anne C, Prescher H, Ruivo R, Sagné C, Debacker C, Bertrand HO, Brossmer R, Acher F, Gasnier B : J Biol Chem, 2012
• Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. (PDF)
  Narboux-Nême N, Sagné C, Doly S, Diaz SL, Martin CB, Angenard G, Martres MP, Giros B, Hamon M, Lanfumey L, Gaspar P, Mongeau R : Neuropsychopharmacology, 2011
• Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis. (PDF)
  Sharifi A, Kousi M, Sagné C, Bellenchi GC, Morel L, Darmon M, Hulková H, Ruivo R, Debacker C, El Mestikawy S, Elleder M, Lehesjoki AE, Jalanko A, Gasnier B, Kyttälä A : Hum Mol Genet, 2010
• Molecular and cellular basis of lysosomal transmembrane protein dysfunction.
  Ruivo R, Anne C, Sagné C, Gasnier B : Biochim Biophys Acta, 2009
• Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.
  Rutsch F, Gailus S, Miousse IR, Suormala T, Sagné C, Toliat MR, Nürnberg G, Wittkampf T, Buers I, Sharifi A, Stucki M, Becker C, Baumgartner M, Robenek H, Marquardt T, Höhne W, Gasnier B, Rosenblatt DS, Fowler B, Nürnberg P : Nat Genet, 2009
• Molecular pathogenesis of sialic acid storage diseases: insight gained from four missense mutations and a putative polymorphism of human sialin.
  Ruivo R, Sharifi A, Boubekeur S, Morin P, Anne C, Debacker C, Graziano JC, Sagné C, Gasnier B : Biol Cell, 2008
• Molecular physiology and pathophysiology of lysosomal membrane transporters.
  Sagné C, Gasnier B : J Inherit Metab Dis, 2008
• Functional characterization of wild-type and mutant human sialin.
  Morin P, Sagné C, Gasnier B : EMBO J, 2004
• Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study.
  Agulhon C, Rostaing P, Ravassard P, Sagné C, Triller A, Giros B : J Comp Neurol, 2003
• Identification and characterization of a lysosomal transporter for small neutral amino acids.
  Sagné C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B : Proc Natl Acad Sci U S A, 2001
• Molecular pharmacology of the vesicular monoamine transporter.
  Henry JP, Sagné C, Botton D, Isambert MF, Gasnier B : Adv Pharmacol, 1998
• The vesicular monoamine transporter: from chromaffin granule to brain.
  Henry JP, Sagné C, Bedet C, Gasnier B : Neurochem Int, 1998
• Noncovalent and covalent labeling of vesicular monoamine transporter with tetrabenazine and ketanserin derivatives; purification of photolabeled protein.
  Henry JP, Sagné C, Isambert MF, Gasnier B : Methods Enzymol, 1998
• The photoactivatable inhibitor 7-azido-8-iodoketanserin labels the N terminus of the vesicular monoamine transporter from bovine chromaffin granules.
  Sagné C, Isambert MF, Vandekerckhove J, Henry JP, Gasnier B : Biochemistry, 1997
• Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases.
  Sagné C, El Mestikawy S, Isambert MF, Hamon M, Henry JP, Giros B, Gasnier B : FEBS Lett, 1997
• SDS-resistant aggregation of membrane proteins: application to the purification of the vesicular monoamine transporter.
  Sagné C, Isambert MF, Henry JP, Gasnier B : Biochem J, 1996
• Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules.
  Henry JP, Botton D, Sagne C, Isambert MF, Desnos C, Blanchard V, Raisman-Vozari R, Krejci E, Massoulie J, Gasnier B : J Exp Biol, 1994
• Expression and regulation of the bovine vesicular monoamine transporter gene.
  Krejci E, Gasnier B, Botton D, Isambert MF, Sagné C, Gagnon J, Massoulié J, Henry JP : FEBS Lett, 1993

Chapter

• Functional Study of Lysosomal Nutrient Transporters
  Leray X, Sagné C, Gasnier B : extracted from Ion and Molecule Transport in Lysosomes Bruno Gasnier, Michael X Zhu - CRC Press, Taylor & Francis Group, ISBN:9781138560390, 2021