Recent Publications

Articles

• MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
  Katharina Esther Julia Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov, Florian Gabriel, Cécile Debacker, Julien Dairou, Isabelle McCort-Tranchepain, Nouf N Laqtom, Sze Ham Chan, Akika Ejima, Kenji Sato, David Massa López, Paul Saftig, Ahmad Reza Mehdipour, Monther Abu-Remaileh, Bruno Gasnier, Christian Löw, Markus Damm : Nature Cell Biology, 2024
• Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.
  Leray X, Conti R, Li Y, Debacker C, Castelli F, Fenaille F, Zdebik AA, Pusch M, Gasnier B : Proc Natl Acad Sci U S A, 2021
• Plug-and-socket mechanisms in nutrient sensing by lysosomal amino acid transporters.
  Gasnier B : Proc Natl Acad Sci U S A, 2021
• Free sialic acid storage disorder: Progress and promise.
  Huizing M, Hackbarth ME, Adams DR, Wasserstein M, Patterson MC, Walkley SU, Gahl WA, FSASD Consortium : Neurosci Lett, 2021
• Transporters in acidic organelles.
  Moriyama Y, Gasnier B : Biochim Biophys Acta Biomembr, 2020
• Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
  Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C : J Med Chem, 2020
• Involvement of thapsigargin- and cyclopiazonic acid-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn.
  Houdou M, Lebredonchel E, Garat A, Duvet S, Legrand D, Decool V, Klein A, Ouzzine M, Gasnier B, Potelle S, Foulquier F : FASEB J, 2019
• Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B-trafficking proteins ABCD4 and LMBD1.
  Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR : J Biol Chem, 2017
• SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
  Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C : Proc Natl Acad Sci U S A, 2017
• Watching the Pulleys Turn while the Elevator Moves in a Secondary Transporter.
  Gasnier B : Biophys J, 2016
• TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.
  Cang C, Aranda K, Seo YJ, Gasnier B, Ren D : Cell, 2015
• Vesicular neurotransmitter transporters: mechanistic aspects.
  Anne C, Gasnier B : Curr Top Membr, 2014
• An extended proteome map of the lysosomal membrane reveals novel potential transporters. (PDF)
  Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A : Mol Cell Proteomics, 2013
• Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.
  Martineau M, Shi T, Puyal J, Knolhoff AM, Dulong J, Gasnier B, Klingauf J, Sweedler JV, Jahn R, Mothet JP : J Neurosci, 2013
• Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. (PDF)
  Jézégou A, Llinares E, Anne C, Kieffer-Jaquinod S, O\\’Regan S, Aupetit J, Chabli A, Sagné C, Debacker C, Chadefaux-Vekemans B, Journet A, André B, Gasnier B : Proc Natl Acad Sci U S A, 2012
• A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport. (PDF)
  Jaenecke I, Boissel JP, Lemke M, Rupp J, Gasnier B, Closs EI : J Biol Chem, 2012
• Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin.
  Ruivo R, Bellenchi GC, Chen X, Zifarelli G, Sagné C, Debacker C, Pusch M, Supplisson S, Gasnier B : Proc Natl Acad Sci U S A, 2012
• Successful prediction of substrate-binding pocket in SLC17 transporter sialin. (PDF)
  Pietrancosta N, Anne C, Prescher H, Ruivo R, Sagné C, Debacker C, Bertrand HO, Brossmer R, Acher F, Gasnier B : J Biol Chem, 2012
• Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.
  Savalas LR, Gasnier B, Damme M, Lübke T, Wrocklage C, Debacker C, Jézégou A, Reinheckel T, Hasilik A, Saftig P, Schröder B : Biochem J, 2011
• Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis. (PDF)
  Sharifi A, Kousi M, Sagné C, Bellenchi GC, Morel L, Darmon M, Hulková H, Ruivo R, Debacker C, El Mestikawy S, Elleder M, Lehesjoki AE, Jalanko A, Gasnier B, Kyttälä A : Hum Mol Genet, 2010
• Insights into lysosomal cobalamin trafficking: lessons learned from cblF disease.
  Gailus S, Höhne W, Gasnier B, Nürnberg P, Fowler B, Rutsch F : J Mol Med (Berl), 2010
• VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. (PDF)
  Amilhon B, Lepicard E, Renoir T, Mongeau R, Popa D, Poirel O, Miot S, Gras C, Gardier AM, Gallego J, Hamon M, Lanfumey L, Gasnier B, Giros B, El Mestikawy S : J Neurosci, 2010
• Molecular and cellular basis of lysosomal transmembrane protein dysfunction.
  Ruivo R, Anne C, Sagné C, Gasnier B : Biochim Biophys Acta, 2009
• Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.
  Rutsch F, Gailus S, Miousse IR, Suormala T, Sagné C, Toliat MR, Nürnberg G, Wittkampf T, Buers I, Sharifi A, Stucki M, Becker C, Baumgartner M, Robenek H, Marquardt T, Höhne W, Gasnier B, Rosenblatt DS, Fowler B, Nürnberg P : Nat Genet, 2009
• The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone.
  Gras C, Amilhon B, Lepicard EM, Poirel O, Vinatier J, Herbin M, Dumas S, Tzavara ET, Wade MR, Nomikos GG, Hanoun N, Saurini F, Kemel ML, Gasnier B, Giros B, El Mestikawy S : Nat Neurosci, 2008
• Molecular pathogenesis of sialic acid storage diseases: insight gained from four missense mutations and a putative polymorphism of human sialin.
  Ruivo R, Sharifi A, Boubekeur S, Morin P, Anne C, Debacker C, Graziano JC, Sagné C, Gasnier B : Biol Cell, 2008
• Molecular physiology and pathophysiology of lysosomal membrane transporters.
  Sagné C, Gasnier B : J Inherit Metab Dis, 2008
• The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. (PDF)
  Aubrey KR, Rossi FM, Ruivo R, Alboni S, Bellenchi GC, Le Goff A, Gasnier B, Supplisson S : J Neurosci, 2007
• The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis.
  Boll M, Daniel H, Gasnier B : Pflugers Arch, 2004
• The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids.
  Gasnier B : Pflugers Arch, 2004
• Molecular pathogenesis of cystinosis: effect of CTNS mutations on the transport activity and subcellular localization of cystinosin.
  Kalatzis V, Nevo N, Cherqui S, Gasnier B, Antignac C : Hum Mol Genet, 2004
• Functional characterization of wild-type and mutant human sialin.
  Morin P, Sagné C, Gasnier B : EMBO J, 2004
• Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina.
  Jellali A, Stussi-Garaud C, Gasnier B, Rendon A, Sahel JA, Dreyfus H, Picaud S : J Comp Neurol, 2002
• Postnatal maturation of Na+, K+, 2Cl- cotransporter expression and inhibitory synaptogenesis in the rat hippocampus: an immunocytochemical analysis.
  Marty S, Wehrlé R, Alvarez-Leefmans FJ, Gasnier B, Sotelo C : Eur J Neurosci, 2002
• A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons.
  Gras C, Herzog E, Bellenchi GC, Bernard V, Ravassard P, Pohl M, Gasnier B, Giros B, El Mestikawy S : J Neurosci, 2002
• Gamma-aminobutyric acid (GABA): a para- and/or autocrine hormone in the pituitary.
  Mayerhofer A, Höhne-Zell B, Gamel-Didelon K, Jung H, Redecker P, Grube D, Urbanski HF, Gasnier B, Fritschy JM, Gratzl M : FASEB J, 2001
• Identification and characterization of a lysosomal transporter for small neutral amino acids.
  Sagné C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B : Proc Natl Acad Sci U S A, 2001
• Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes.
  Kneussel M, Brandstätter JH, Gasnier B, Feng G, Sanes JR, Betz H : Mol Cell Neurosci, 2001
• Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter.
  Kalatzis V, Cherqui S, Antignac C, Gasnier B : EMBO J, 2001
• The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons.
  Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C, Gasnier B, Giros B, El Mestikawy S : J Neurosci, 2001
• Constitutive phosphorylation of the vesicular inhibitory amino acid transporter in rat central nervous system.
  Bedet C, Isambert MF, Henry JP, Gasnier B : J Neurochem, 2000
• Formation of mixed glycine and GABAergic synapses in cultured spinal cord neurons.
  Dumoulin A, Lévi S, Riveau B, Gasnier B, Triller A : Eur J Neurosci, 2000
• The loading of neurotransmitters into synaptic vesicles.
  Gasnier B : Biochimie, 2000
• Presence of the vesicular inhibitory amino acid transporter in GABAergic and glycinergic synaptic terminal boutons.
  Dumoulin A, Rostaing P, Bedet C, Lévi S, Isambert MF, Henry JP, Triller A, Gasnier B : J Cell Sci, 1999
• Molecular dissection of regulated secretory pathways in human gastric enterochromaffin-like cells: an immunohistochemical analysis.
  Höcker M, John M, Anagnostopoulos J, Buhr HJ, Solimena M, Gasnier B, Henry JP, Wang TC, Wiedenmann B : Histochem Cell Biol, 1999
• Molecular pharmacology of the vesicular monoamine transporter.
  Henry JP, Sagné C, Botton D, Isambert MF, Gasnier B : Adv Pharmacol, 1998
• The vesicular monoamine transporter: from chromaffin granule to brain.
  Henry JP, Sagné C, Bedet C, Gasnier B : Neurochem Int, 1998
• Noncovalent and covalent labeling of vesicular monoamine transporter with tetrabenazine and ketanserin derivatives; purification of photolabeled protein.
  Henry JP, Sagné C, Isambert MF, Gasnier B : Methods Enzymol, 1998
• The photoactivatable inhibitor 7-azido-8-iodoketanserin labels the N terminus of the vesicular monoamine transporter from bovine chromaffin granules.
  Sagné C, Isambert MF, Vandekerckhove J, Henry JP, Gasnier B : Biochemistry, 1997
• Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases.
  Sagné C, El Mestikawy S, Isambert MF, Hamon M, Henry JP, Giros B, Gasnier B : FEBS Lett, 1997
• SDS-resistant aggregation of membrane proteins: application to the purification of the vesicular monoamine transporter.
  Sagné C, Isambert MF, Henry JP, Gasnier B : Biochem J, 1996
• Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules.
  Henry JP, Botton D, Sagne C, Isambert MF, Desnos C, Blanchard V, Raisman-Vozari R, Krejci E, Massoulie J, Gasnier B : J Exp Biol, 1994
• Expression of a bovine vesicular monoamine transporter in COS cells.
  Gasnier B, Krejci E, Botton D, Massoulié J, Henry JP : FEBS Lett, 1994
• The catecholamine transporter of adrenal medulla chromaffin granules.
  Henry JP, Gasnier B, Desnos C, Scherman D, Krejci E, Massoulié J : Ann N Y Acad Sci, 1994
• Expression and regulation of the bovine vesicular monoamine transporter gene.
  Krejci E, Gasnier B, Botton D, Isambert MF, Sagné C, Gagnon J, Massoulié J, Henry JP : FEBS Lett, 1993
• Characterization and purification of the monoamine transporter of bovine chromaffin granules.
  Isambert MF, Gasnier B, Botton D, Henry JP : Biochemistry, 1992
• Photoaffinity labeling of the monoamine transporter of bovine chromaffin granules and other monoamine storage vesicles using 7-azido-8-[125I]iodoketanserin.
  Isambert MF, Gasnier B, Laduron PM, Henry JP : Biochemistry, 1989
• Hydrophobicity of the tetrabenazine-binding site of the chromaffin granule monoamine transporter.
  Scherman D, Gasnier B, Jaudon P, Henry JP : Mol Pharmacol, 1988
• Molecular pharmacology of the monoamine transporter of the chromaffin granule membrane.
  Henry JP, Gasnier B, Roisin MP, Isambert MF, Scherman D : Ann N Y Acad Sci, 1987
• Functional molecular mass of binding sites for [3H]dihydrotetrabenazine and [3H]reserpine and of dopamine beta-hydroxylase and cytochrome b561 from chromaffin granule membrane as determined by radiation inactivation.
  Gasnier B, Ellory JC, Henry JP : Eur J Biochem, 1987
• Inactivation of the catecholamine transporter during the preparation of chromaffin granule membrane ’ghosts’.
  Gasnier B, Scherman D, Henry JP : FEBS Lett, 1987
• Characterization of low- and high-affinity glucose transports in the yeast Kluyveromyces marxianus.
  Gasnier B : Biochim Biophys Acta, 1987
• [Molecular pharmacology of the catecholamine transporter of chromaffin granules from the bovine adrenal medulla].
  Henry JP, Scherman D, Roisin MP, Gasnier B, Isambert MF : Biochimie, 1986
• Uptake of meta-iodobenzylguanidine by bovine chromaffin granule membranes.
  Gasnier B, Roisin MP, Scherman D, Coornaert S, Desplanches G, Henry JP : Mol Pharmacol, 1986
• Dicyclohexylcarbodiimide inhibits the monoamine carrier of bovine chromaffin granule membrane.
  Gasnier B, Scherman D, Henry JP : Biochemistry, 1985

Book

• Ion and Molecule Transport in Lysosomes
  Bruno Gasnier, Michael X Zhu : CRC Press, Taylor & Francis Group, ISBN:9781138560390, (239 pages), 2020

Chapter

• Functional Study of Lysosomal Nutrient Transporters
  Leray X, Sagné C, Gasnier B : extracted from Ion and Molecule Transport in Lysosomes Bruno Gasnier, Michael X Zhu - CRC Press, Taylor & Francis Group, ISBN:9781138560390, 2021