News
Heating, not highly non-linear photo damage is limiting for 920-nm 2-imaging
Unraveling how neural networks process and represent sensory information and how these cellular signals instruct behavioral output is a main goal in neuroscience. Two-photon activation of optogenetic actuators and calcium (Ca 2+) imaging with gen ...
Open Post-doctoral position at the Saints-Pères Paris Institute for Neurosciences (Université de Paris)
OPEN POSTDOC Development of a compressed wavefront sensor with a thin scattering Hartmann-mask We offer a 15-month postdoc position (renewable 15 months) starting on January 2021, funded by the french national agency (ANR) for developing a compr ...
Open PhD position at the Saints-Pères Paris Institute for Neurosciences (Université de Paris)
OPEN PHD in Zytnicki lab Title: “Restoration of excitation/inhibition balance to modulate motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS)“ A PhD position, under the supervision of Daniel Zytnicki, is available in the ...
Internship offer 2020-2021 for master project : “Immunolabelling of cleared thick three-dimensional brain sections”
INTERNSHIP OFFER, Oheim lab, academic year 2020-21 MASTER PROJECT: Immunolabelling of cleared thick three-dimensional brain sections Fluorescent-protein expression in genetically identified cell populations, along with advances in tissue clearing [Con15, R ...
Internship offer 2020-2021 for master project : “Labelling of active astrocytes with genetically encoded Calcium integrators – an in vitro proof-of-concept study.”
INTERNSHIP OFFER, Oheim lab, academic year 2020-21 MASTER PROJECT: Labelling of active astrocytes with genetically encoded Calcium integrators – an in vitro proof-of-concept study. About half of the cells in the human brain are not neurons. Our aim is to ...
Spectral correlations in forward scattering media
Artist illustration of chromatic speckle expansion after a scattering sample. (© Clément Molinier) Imaging deep in scattering tissues has been typically achieved by exciting non-linear optical processes thanks to broadband ultrashort laser pulses. Scatte ...
The SPPIN supports Paris Hospitals in times of Corona
Together with other laboratories of the Saints Pères Biomedical Sciences Site (Campus Saint Germain) the SPPIN has collected consumables and lab material in support of the Necker, Cochin Hospitals on the left bank and Bichat, Lariboisière, Baujon Hospita ...
STANISLAS PhD project selected by CNRS and U. Toronto
The CNRS and the University of Toronto selected a joint PhD-and research grant involving SPPIN’s team 1 (Oheim) and the laboratory of Molecular Biophysics at the Department of Biochemistry (Yip) at U Toronto. In the framework of this 3-year research coll ...
Evanescence in emission: seeing fluorescence from supercritical angles
Read it here : Supercritical angle microscopy and spectroscopy Authors: Martin Oheim, Adi Salomon, Maia Brunstein Abstract: Fluorescence detection, either involving propagating or near-field emission, is widely being used in spectroscopy, sensing and micro ...
JacSue Kehoe
The SPPIN laboratory deeply regrets to announce the death of JacSue Kehoe on 25 june 2019, at the age of eighty-three. JacSue spent decades working with the neurons of Aplysia californica, studying the post-synaptic nerve response. Among many other things, ...
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Fresh from the press
Articles
- Rapid Motor Adaptation via Population-level Modulation of Cerebellar Error Signals
Vinh Nguyen, Brandon M Stell : (preprint), in press - Associative plasticity of granule cell inputs to cerebellar Purkinje cells
Rossella Conti, Céline Auger : (preprint), in press - Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.
Nascimento F, Özyurt MG, Halablab K, Bhumbra GS, Caron G, Bączyk M, Zytnicki D, Manuel M, Roselli F, Brownstone R, Beato M : Cell Rep, 2024 - Contributions of Surface and Interface Physical Chemistry to Biology
Ahmed Hamraoui : (preprint), 2024 - Hyperspectral wavefront sensing with a multicore fiber
Baptiste Blochet, Nathalie Lebas, Pascal Berto, Dimitrios Papadopoulos, Marc Guillon : (preprint), 2024 - A Polarimetric Wavefront Imager
Baptiste Blochet, Grégoire Lelu, Miguel A Alonso, Marc Guillon : (preprint), 2024 - Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex
Louis Richevaux, Dongkyun Lim, Mérie Nassar, Léa Dias Rodrigues, Constanze Mauthe, Ivan Cohen, Nathalie Sol-Foulon, Desdemona Fricker : (preprint), 2024 - Presubicular VIP expressing interneurons receive facilitating excitation from anterior thalamus.
Nassar M, Richevaux L, Lim D, Tayupo D, Martin E, Fricker D : Neuroscience, 2024 - Brain inflammation and cognitive decline induced by spinal cord injury can be reversed by spinal cord cell transplants
Quentin Delarue, Amandine Robac, Celia Duclos, Baptiste Pileyre, Clemence Raimond, Pauline Neveu, Gaetan Riou, Nicolas Guerout : (preprint), 2024 - Involvement of kinases in memory consolidation of inhibitory avoidance training.
Montiel I, Bello-Medina PC, Prado-Alcalá RA, Quirarte GL, Verdín-Ruvalcaba LA, Marín-Juárez TA, Medina AC : Rev Neurosci, 2024 - Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor.
Matsingos C, Howell LA, McCormick PJ, Fornili A : J Mol Biol, 2024 - The gut, a whistleblower, in the early stages of Parkinson’s disease
Doriane Hazart, Malvyne Rolli-Derkinderen, Brigitte Delhomme, Pascal Derkinderen, Martin Oheim, Clément Ricard : Médecine/sciences, 2024 - Characterizing human astrocyte calcium signaling in a cerebral organoid
Kaitlin Szederkenyi, Liliana Attisano, Martin Oheim, Christopher M Yip : Biophys J, 2024 - L’intestin, lanceur d’alerte, dans les prémices de la maladie de Parkinson
Doriane Hazart, Malvyne Rolli-Derkinderen, Brigitte Delhomme, Pascal Derkinderen, Martin Oheim, Clément Ricard : Médecine/sciences, 2024 - Complementary Speckle STED Microscopy
Payvand Arjmand, Samlan Chandran Thodika, Elsa Bivas, Haoyang Li, Martin Oheim, Hiroyuki Yoshida, Etienne Brasselet, Marc Guillon : (preprint), 2024 - Lesion-induced impairment of therapeutic capacities of olfactory ensheathing cells in an autologous transplantation model for treatment of spinal cord injury
Quentin Delarue, Matthis Brodier, Pauline Neveu, Laurine Moncomble, Alizée Hugede, Axelle Blondin, Amandine Robac, Clémence Raimond, Pamela Lecras, Gaëtan Riou, Nicolas Guérout : (preprint), 2024 - Complementarity between Brillouin signature and Scholte wave for controlled elasticity in fibrillated collagen medium for culture cell
Ahmed Hamraoui, Océane Sénépart, Laurent Belliard : Applied Physics Letters, 2024 - MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
Katharina Esther Julia Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov, Florian Gabriel, Cécile Debacker, Julien Dairou, Isabelle McCort-Tranchepain, Nouf N Laqtom, Sze Ham Chan, Akika Ejima, Kenji Sato, David Massa López, Paul Saftig, Ahmad Reza Mehdipour, Monther Abu-Remaileh, Bruno Gasnier, Christian Löw, Markus Damm : Nature Cell Biology, 2024 - Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain.
Cristiano N, Cabayé A, Brabet I, Glatthar R, Tora A, Goudet C, Bertrand HO, Goupil-Lamy A, Flor PJ, Pin JP, McCort-Tranchepain I, Acher FC : J Med Chem, 2024 - Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques.
Eshak F, Pion L, Scholler P, Nevoltris D, Chames P, Rondard P, Pin JP, Acher FC, Goupil-Lamy A : J Chem Inf Model, 2024 - Ice templating water-stable macroporous polysaccharide hydrogels to mimic plant stems.
Komiyama K, Allard M, Eschenbrenner C, Sicard C, Hamraoui A, Fernandes F : (preprint), 2024 - CBX3 antagonizes IFNγ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity.
Xiang Y, Mata-Garrido J, Fu Y, Desterke C, Batsché E, Hamaï A, Sedlik C, Sereme Y, Skurnik D, Jalil A, Onifarasoaniaina R, Frapy E, Beche JC, Alao R, Piaggio E, Arbibe L, Chang Y : EMBO Mol Med, 2024 - Single-shot digital optical fluorescence phase conjugation through forward multiple-scattering samples
TENGFEI WU, YIXUAN ZHANG, BAPTISTE BLOCHET, PAYVAND ARJMAND, PASCAL BERTO, AND MARC GUILLON : Science advances, 2024 - Multiplexed wavefront sensing with a thin diffuser
Tengfei Wu, Marc Guillon, Gilles Tessier, and Pascal Berto : Optica, 2024 - Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu(2) Receptor Agonist.
Liu N, Eshak F, Malhaire F, Brabet I, Prézeau L, Renard E, Pin JP, Acher FC, Staudt M, Bunch L : J Med Chem, 2024 - A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse.
Silva M, Tran V, Marty A : Elife, 2024 - A colour-encoded nanometric ruler for axial super-resolution microscopies
Ilya Olevsko, Omer Shavit, Moshe Feldberg, Yossi Abulafia, Adi Salomon, Martin Oheim : Optics Communications, 2024 - [Neural bases of memory and spatial navigation].
Tran TH, El Mahzoum R, Fricker D, Cohen I, Bonnot A : Med Sci (Paris), 2023 - Morphological Heterogeneity of Astrocytes in a Cerebral Organoid
K Szederkenyi, L Attisano, M Oheim, CM Yip : Glia, 2023 - Methods and applications in frontiers in neuroanatomy
Clément Ricard, Lidia Alonso-Nanclares, Basilis Zikopoulos, Martin Oheim : Front Neuroanat, 2023 - The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase–LRP4 receptor complex by agrin at the neuromuscular junction
Thi Minh Uyen Dao, Susie Barbeau, Julien Messéant, Bruno Della-Gaspera, Tahar Bouceba, Fannie Semprez, Claire Legay, and Alexandre Dobbertin : J Biol Chem, 2023 - Advances in Spinal Cord Neuromodulation: The Integration of Neuroengineering, Computational Approaches, and Innovative Conceptual Frameworks.
Pradat PF, Hayon D, Blancho S, Neveu P, Khamaysa M, Guerout N : J Pers Med, 2023 - Mesenchymal calcium waves underpin intestinal smooth muscle differentiation
Chevalier N R, Zig L, Gomis A, Amedzrovi Agbesi R, Pontoizeau L, Eude-Le Parco I, Rouach N, Arnoux I, De Santa Barbara P, Faure S : Communications Biology, 2023 - Electrical and Mechanosensitive Activity of the Mouse Fetal Enteric Nervous System
Amedzrovi Agbesi R, Spencer N, Hebberd T, Chevalier N R : J Physiol, 2023 - Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells.
Schenberg L, Palou A, Simon F, Bonnard T, Barton CE, Fricker D, Tagliabue M, Llorens J, Beraneck M : Elife, 2023 - Beneficial Effect of Bee Venom and Its Major Components on Facial Nerve Injury Induced in Mice.
Er-Rouassi H, Bakour M, Touzani S, Vilas-Boas M, Falcão S, Vidal C, Lyoussi B : Biomolecules, 2023 - PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.
Alber S, Di Matteo P, Zdradzinski MD, Dalla Costa I, Medzihradszky KF, Kawaguchi R, Di Pizio A, Freund P, Panayotis N, Marvaldi L, Doron-Mandel E, Okladnikov N, Rishal I, Nevo R, Coppola G, Lee SJ, Sahoo PK, Burlingame AL, Twiss JL, Fainzilber M : Sci Adv, 2023 - Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum.
Le Guellec B, Gomez LC, Malagon G, Collin T, Marty A : J Gen Physiol, 2023 - Prioritized docking of synaptic vesicles provided by a rapid recycling pathway
Tran V, Silva M, Marty A : IScience, 2023 - Bumetanide increases postsynaptic inhibition after chronic SCI and decreases presynaptic inhibition with step-training.
Caron G, Bilchak J, Côté MP : J Physiol, 2023 - KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.
Kassa M, Bradley J, Jalil A, Llano I : J Gen Physiol, 2023 - Characterizing nanometric thin films with far-field light
Klimovsky H, Shavit O, Julien C, Olevsko I, Hamode M, Abulafia Y, Suaudeau H, Armand V, Oheim M, Salomon A : Adv Opt Mater, 2023