24th september 2024 – Pablo BLINDER – The circuit basis of stereo vision

Prof Pablo BLINDER, Neurobiology, Biochemistry and Biophysics School,George S. Wise Faculty of Life Sciences, and Sagol School for Neuroscience, Tel Aviv University

SPPIN’s webinar 2024, 5 June at 10h30, R229 (after the progress report)

Exploring the impact of blood flow perturbations on brain structure and function.

It is intuitive and widely accepted, to consider unperturbed blood supply to the brain as mandatory for its proper function. As such, blood flow is increased around active areas of the brain in a process known as neurovascular coupling. I would like to refer to this as the “forward” direction of neurovascular coupling. I will share our efforts to decode, at the cellular level, the neurovascular transfer function from data we collected through volumetric 2-phon microscopy. On the flip side, extreme perturbations to blood flow, such as ischemic events, are know to affect brain structure and function. Whether more subtle changes in blood flow can affect neuronal activity is still largely unknown. We explore a range of such perturbations, from week-long changes to the fast pulsatile changes associated with each single heartbeats; this in an effort to identify the “backward” direction of neurovascular coupling to form a conceptually closed regulatory loop.

Host: Martin Oheim. contact him if you want to meet with Pablo